Saturday, March 19, 2022

Materials for PGY-1

 So I matched in pathology and I'm extremely happy!!

I'll be posting resources here that I feel may be useful for an incoming trainee.

Hopefully this will be helpful to other incoming residents as well as myself.

Weblinks:

http://kurtsnotes.net/ 

Books:

Yet to get recommendations


Will update with more as time goes on...

Congrats to everyone who matched.

Thursday, September 2, 2021

Pathology Elective

 Hi everyone,

I came across this website recently and I would recommend it to anyone considering pathology as a specialty in medicine.

It's called Pathology Elective. Here is the link.

I just learned about this and I'm excited to explore this site more!

Thanks everyone, until next time~

P.S. another site I found mentioned on the site above is Web Pathology.  

Sunday, May 30, 2021

Interesting cases

 Hi everyone, 

It's been a looong time since I made a post.

Recently I came across Ohio State University's Case of the Week series here.

They also have dermatopathology interesting cases here

Enjoy!

Tuesday, June 23, 2020

Summer is here!

Hi everyone,

There has been a great deal of unrest the past few weeks here in the USA with rising case numbers of coronavirus in select states and protester-police clashes resulting in violence and destruction... despite all this, the summer is kicking off with blossoms and nature's bounty all around us.

I thought I'd share a few resources I've come across, and review a few books which I had time to read recently.

Resources:

MGH Learn Pathology has curated virtual slide sets
Johns Hopkins Pathology many resources here

Book reviews:

Five Days at Memorial: Life and Death in a Storm-Ravaged Hospital by Sheri Fink
- The book chronicles the events surrounding Hurricane Katrina at Ochsner Baptist Medical Center (then known as Memorial Medical Center) in 2005. Thoughts: Similar strains to the pandemic we are experiencing now, with extreme (and I would argue unethical) "care rationing" taking place. Superb investigative journalism.

Forensic Detective: How I Cracked the World's Toughest Cases by Robert Mann
- Forensic anthropologist recalls fascinating cases which traverse time and continents from Hawaii to Vietnam and back. Advances in forensic science help identify unknown remains (mitochondrial DNA).

Currently reading:

No Stone Unturned by Steve Jackson
Details NecroSearch's attempts to find human remains and assist with cold cases.

What is on your summer reading list?

Monday, April 27, 2020

Covid-19 and Pathology

Hi everyone,

The coronavirus pandemic has caused many changes in the last month or so in the United States. People are advised to stay at home and maintain distance from each other, not travel, see their family and friends, in addition to wearing masks, in addition to staying away from large gatherings. Most non-essential businesses such as hair salons have closed and restaurants are either closed or only offering take-out. Elective surgery and non-emergent doctor's visits have been canceled or rescheduled.

Many people have filed for unemployment. Covid-19 has upended livelihoods and caused social changes which may last for the next 1-2 years, not to mention the massive government financing of companies and businesses here in America. Thankfully, of the people I know personally, they have kept their jobs and are working from home or going to the office very rarely.

In terms of medical training, the consensus among medical schools, in general, is that medical trainees should not be in the clinics/hospital during this time. My medical school's policy is that medical students should not physically attend rotations for the time being. The educational components are being completed from home virtually. In my masters of public health, all the classes are being taught remotely.

It has been interesting to compare the public health response of different countries and the actions they have taken against the novel coronavirus. In some countries, aggressive contact tracing and widespread testing has managed to curb or contain the spread of the virus. In the US, the government's sluggish and piecemeal response has made it difficult to effectively contain the virus. An example is the use of a smartphone app to trace the people a person could have been in close contact with, if they are found to test positive for coronavirus.

Hospitals and healthcare workers in New York, the epicenter of the pandemic in the North East US, have been overwhelmed by Covid-19 cases. In addition, the shortage of PPE (personal protective equipment) such as facemasks, gowns, and gloves in addition to other healthcare equipment has exacerbated the crisis.

Many features are being uncovered as the pandemic progresses. One example, that has come out recently is that Covid-19 can cause a coagulopathy leading to strokes or pulmonary embolism in young people. Another is that the virus may cause cardiac symptoms in individuals, causing medical examiners to erroneously attribute their deaths to cardiac cause without sufficient testing of the decreased. Without testing, there is likely an undercounting of deaths related to coronavirus here in the United States.

One fear is that the virus will mutate as it passes from host to host and grow more and more virulent as time passes. The other fear, is that we will not be able to find an effective vaccine for the virus. The hope of returning to normality hinges on the creation of a vaccine or finding an effective treatment. There have been some attempts to use convalescent plasma, however it is unclear how much of a benefit it will provide, in addition to there not being enough plasma available (in addition to the usual transfusion risks although it is generally tolerated well). Like many things about this situation, convalescent plasma from recovered Covid-19 patients has not been extensively tested.

Unfortunately, there has been a lot of misinformation circulating about which treatments may be effective against the virus, ranging to medications to homeopathy. This is troubling and misguided  because it can lead to shortages in essential medicines needed to treat other diseases that are not related to the pandemic.

As difficult it is to stay away from loved ones and conduct our daily lives from home, it is necessary to take precautions to prevent the spread of this highly contagious virus. I hope that pathologists and researchers will be able to contribute to scientific knowledge about Covid-19 as things progress, in order to prevent morbidity and mortality. Now more than ever, we must cooperate to prevent this pandemic from worsening.

How have you been effected by Covid-19?

Have there been changes to your workplace (or pathology laboratory) as a result of the coronavirus pandemic?

Feel free to share any thoughts or comments.

Monday, February 10, 2020

Forensics & Injury Prevention

Hi everyone,

It has been forever since I made a post, so I figured I might as well write something here.

As my acquaintances and friends may know, this year I am pursuing a masters in public health as a dual degree with my medical degree. I have learned a lot so far that I think will be useful in the future. One of the topics which I am concentrating on in public health is injury prevention. This is essential the study of what causes injury/death and how to prevent such things from happening. Some topics which we cover are gun violence, drug overdose/opioid crisis, and other social woes. Many of the issues which effect injury prevention on the child population actually has to do with product design (toys, cribs, window blinds, etc.) P.S. Don't buy metal straws.

On the side, I've been reading more books about forensics.

Some of the titles I have enjoyed so far (in order of reading):
  • The Poisoner's Handbook: Murder and the Birth of Forensic Medicine in Jazz Age New York by Deborah Blum
  • Mortal Evidence: The Forensics Behind Nine Shocking Cases by Cyril Wecht
  • Morgue: A Life in Death by Vincent DiMaio
  • Working Stiff: Two Years, 262 Bodies, and the Making of a Medical Examiner by Judy Melinek
  • Dissecting Death: Secrets of a Medical Examiner by Frederick Zugibe
There is an incredible amount of controversy surrounding some of the cases discussed in these books. They are undoubtedly career-defining cases. It certainly does not make for light reading, though I think I enjoyed reading these titles most at nighttime before bed.

What I learned from watching videos/crime scene reconstructions, digging deeper into some of these cases is that the press sometimes gets the details wrong in their reporting.

Then again, I suppose there is a great asymmetry in information when it comes to this subject in particular.

Some interesting sub-fields are forensic anthropology and forensic entomology (the study of insects).

What books/novels do you recommend?

Monday, September 23, 2019

CAP meeting

Hi everyone,

I want to share resources which I encountered at the College of American Pathologists (CAP) meeting in Orlando, Florida this year.

PathPresenter

Please check these out, I think they are both outstanding.

(Path presenter is incomplete in some sections. They need help annotating some parts actually, so if you would like to help you can contact via website.)

If you are a medical student, see CAP for medical students.
CAP Foundation has started a Lunch & Learn program for medical student pathology interest groups. Please see site for more information.
There is also the Travel Award, which awards up to $1200 to attend the annual meeting!

If you are helping coordinate the pathology interest group at your medical school, please see PathologyTraining.org (aka ICPI, Intersociety Council for Pathology Info). They provide $600-$500 dollars annually for Pathology interest groups.

These are great opportunities, and I encourage those interested to apply. ^_^

Wednesday, June 5, 2019

Bones

Wow, it feels like a really long time since I made a blog post.

Over the past 2 weeks or so since getting back from Japan, I've been busy moving. After I moved into my new place I read the 4th edition of Orthopedic Pathology by Peter Bullough (Hosp. for Spec. Surgery in NY). A 5th ed is available, but I'm reading the late edition (since it's the only physical copy the library has). The reason I wanted to read this is because of the few times I came across bone (not in the context of bone marrow biopsy for hemepath), I felt like I had very little idea/knowledge regarding what I was looking at.

It's a really good book and I recommend it. It goes into gory detail about all things bone. Something which surprised me about this book, is it mentioned having radiologist input, which I thought would last for a few chapters or so then peter out, but it has consistent rad-path correlates pretty much the whole way through the book which I think is quite commendable. It also has really good examples of disease entities which are rare. It always amazes me how the specimens are presented in this book... very clearly, which I assume must have taken hours of careful dissection to prepare. Something which I keep wondering while reading this book, is what their gross room setup looks like. I assume it is something similar to a carpenter's shop with huge razors and the like for sawing through bones. It shows some of their gross room in the introductory section, but it would be very cool to get a tour someday.

The book would be a good read for future radiologists as well, as it goes through differential diagnoses and mimickers.

Reading this book also made me realize how much special equipment is necessary to conduct a comprehensive assessment of bone... half of the pictures in here have polarized light microscopy and a lot of special stains are used, in addition to red filter for gout and CPPD.

An interesting point that I think I got from this book is that bone pathology is very easily confused on imaging. For example, some of the benign entities discussed were removed because they were mistaken for malignant processes. This happens in other areas of pathology as well, but I suppose in bone it is more high-stakes. In other instances, a malignant lesion can be confused for a benign process... This is one area in which I wonder if molecular genetics could be very helpful in pinning down a diagnosis.

What resources do you recommend for learning bone pathology?





Friday, March 29, 2019

Forensic Pathology

So I am currently 1/3 of the way through the ob/gyn rotation, and unfortunately (due to very stupid reasons) I'm not enjoying it as much as I had hoped. 40 days until Japan...

In other news, I just finished reading this book called "Unnatural Causes" by Dr. Richard Shepherd.

The author writes about his career as a forensic pathologist in Britain/the UK. He writes very honestly, and I was hooked on this book from the very beginning when I first read the introduction online later reading the physical copy in very short drips and drabs at night before bed.

As of now I'm not sure what kind of career in pathology I want to pursue.

I find that I enjoy looking at slides, but I have also become interested in topics in forensic pathology.

We had one lecture (and only one) given to us by a practicing forensic pathologist and this was outside the curriculum of medical school -- in fact, it was through the activities of the pathology interest group that I first became aware that this was even a career option. Later I had the opportunity to observe a few forensic post-mortems, but I am not completely sure it's what I want to do because I'm between that and being a hospital/clinical pathologist.

One book which I think is a good starting resource would be the textbook Forensic Pathology by David Dolinak who is both a neuropathologist and a forensic pathologist. I read the entire book over a few months time. It was a very fascinating book, though I was unable to read it at length, given the material/content. I had to read it very slowly in small portions at a time. There was something fascinating about it that pushed me to read it to the end, however, similar to Dr. Shepherd's book.

Shepherd talks about his experience having PTSD which he attributes to having worked in post-disaster/massacre/terrorist situations i.e. 9/11, Hungerford massacre, Bali, Marchioness tragedy

It's strange, before this, I thought I had all but decided I wanted to look at slides all day instead of doing autopsies. I'm not sure if I'm being influenced by the unsavory interactions I'm having with the clinicians that I'm working with right now. Is it a reaction that I'm having by wanting to distance myself entirely from the microcosm of the hospital, the egos and squabbles of the clinicians, and their politics (?)

The other reason why I'm considering this again (forensics) even though previously I thought I had ruled it out as a career [...thinking back, it may have been because of my role of relative non-involvement as a student who was there on a very limited basis, essentially observing and not having a very active role in the autopsies I observed] have to do with my own curiosity and interest and I suppose a natural affinity for the job I suppose. Being able to determine why a person died is not as simple as it appears...

Either way, I guess because of this book and for my own reasons, I'm thinking about this career path again.

Two additional resources I would recommend for people interested in forensic pathology specifically would be Knight's forensic pathology (found easily online), and Simpson's Forensic Medicine (I was able to find the 11th edition in the library and flipped through it, but I would like to check out the most recent edition which I'm sure has a lot more updates).

One thing that does bother me would be the occupational hazards inherent to the job in terms of infectious disease. I have heard here and there about pathologists contracting various diseases on the job. Perhaps, given the infectious risk, there needs to be more formalized protocols when carrying out an autopsy, similar to how surgery in the past used to be much less regulated in terms of protocol leading to mistakes and surgical site infections.

What are some ways you all think infection risk could be reduced when carrying out an autopsy?

Monday, March 18, 2019

The Match and Ob/Gyn

Hey everyone, this past week was quite momentous as (medical readers likely know) it was Match Day just last Friday (in addition to it being St. Patrick's Day Sunday).

Match Day is the day where all the fourth year medical students in the country find out the location of the residency program where they will be working in residency (a.k.a. first real job out of medical school).  It marks the transition from being a 'medical student' to being a resident 'doctor' although still a trainee. For my close friends, some of them matched to their top choice program, while for others they matched further down the list (i.e. in more competitive specialties, for example).

The rules are that the applicant creates a 'rank list' which lists the programs where the person would like to go to, and the program creates their own list of applicants. A computer program takes this massive amount of data, crunches it, and matches person to program.

On the actual Match day ceremony (typically a Friday), students, their friends and family receive and open the letters containing information about the hospital and the location where they will be working for the next several years. It is similar to other ceremonies (weddings, funerals) that commemorate and mark an important transition in one's life.

Even so, there are imperfections.

The difficulty of the match system is that one has very little control over where one actually ends up, given that it is determined by a computer algorithm.

It is especially difficult when couples are separated by this system. Even the 'couples match' (two applicants declare themselves 'a couple' and tries match them to programs within the same general region) can result in applicants being separated by hours. So what is the solution to this problem?

From what I understand ... one has to have two things - faith, persistence, and strategy. Expressing interest in a certain program in a desired geographic region can raise an applicant's rank on a program's list. Applying to many programs in the region of interest also increase one's chances of matching in a geographic area. And finally, doing an away rotation at an institution one would like to be at. Other than the things applicants typically do which consists of doing well on exams and making a good impression on an interview. The converse of which is what people applying have told me is referred to as 'avoiding red flags' (i.e. failing an exam, making a bad impression on an interview).

On a completely unrelated note, I finished my surgery rotation last week.

Today I just had my first day of conferences for my Ob/Gyn rotation. I realized that it is a completely different language! Obstetrician-gynecologists communicate using unique terminology which you do not hear in any other field of medicine! It was kind of a shocker how much I realized I didn't know about the female body and pregnancy. I have a lot to learn the next 6 weeks.

An interesting conversation between two ob/gyn's which I overheard today was regarding the sufficiency of cytology specimens. One remarked that sometimes his samples resulted as insufficient for evaluation, and a few tricks/tips to avoid this. A suggestion was : because blood cells an obscure a sample, do not over-instrumentate while taking a sample. The other talked about how she improved by avoiding getting lubricant in the sample by ensuring that it was on the outer blades of the speculum (while doing a pelvic exam). It got me thinking about how to improve the yield of cytology specimens. She did discuss some laboratory factors such as compatibility of the media with machines used to process specimens etc. Due to variability in these factors, I would assume the yield varies between laboratories and it is interesting to think about how to potentially increase yield and specimen quality given the quantity given. This is a frustrating point for obstetrician-gynecologists because it means that the patient must come back for another visit, taking a chunk out of her day, and ultimately leading to decreased rapport and patient satisfaction, due to factors out of their control.

Hearing the clinician perspective about this made me realize how important it is for laboratory professionals to handle specimens with care, but also troubleshoot and make improvements in our own processes so that patients do not undergo extra procedures unnecessarily.

As much as people might say (as one surgery resident did to me just the other day in the OR), in pathology, "all your patients are dead", this illustration begs to differ. The information we relay to clinicians has an enormous impact on medical decision making, and we should consider carefully the message and potential impact/consequences. A very important way of framing this, I think, is by considering the range of actions a clinician might make based on the information contained in the report, as a thought exercise. For example, I was told by a surgery resident that even though a diagnosis may not be certain, a surgeon may choose to bring a patient to the OR simply based on a 'highly suspicious' diagnosis, in some cases. Of course this is on a case-by-case basis and clinical judgement, but it is always important to consider.

This brings up a few questions, such as: What happens when an interpretation gets out of hand? For example, a pathologist has made an equivocal diagnosis favoring two possibilities and it is interpreted as being 'entity X' (error of omission) in the patient's medical chart/clinician's notes. Is the role of the pathologist to point out this discrepancy and effectively impose oneself by correcting the people involved in the patient's medical care? This is an interesting ethical dilemma for pathologists as some might argue it is overstepping our bounds. Another sticky situation involves a pathologic diagnosis that is failed to be followed up on, effectively being missed by clinicians in review of the patient's charts. Should a pathologist be more proactive in alerting busy clinicians of the findings? Which would be the best way to do this (by letter, phone call)? Should we as pathologists take a more proactive role in improving our communication to the healthcare providers ultimately responsible for keeping track of the patient's medical course (?)

This weekend, I also went to donate blood again, seeing that it had been about 3 months, and I had some free time, and this very nice lady from the Red Cross phoned me and asked whether I would be available. I figured, hey, I have the weekend off after my surgery shelf exam, so why not? I had about 2 weeks to prepare in advance (whereas previously I just did it on a whim). So I went, having hydrated myself nightly the week in advance (was sipping on clears at home). To my surprise, I was able to complete the donation. Fun fact: Did you know there is about a pint or just under 500 ml (half a liter) in a pack of whole blood? I give credit to the incredible staff at the Red Cross who were able to place the needle even though I have small veins, and watched me carefully after the donation. The people who work there really do care.

The hours on this rotation are 5-6AM to 6PM, typically. With 2 weeks of L&D, Gynecologic surgery, and clinic. I think after this rotation, I will have more time to post again. =)

Friday, February 8, 2019

Surgery and Autopsy

Hi everyone,

I'm on my surgery rotation this block and it is pretty grueling.

The best part of the rotation is that I get to 'follow the specimen' to the frozen/cutting room once the operation is almost over. The worst part is the hours (sleep deprivation much?). And the residents are really snappy. This is gen surg btw. [For anyone interested: the hours are the following: Wake up at 4 am, get to hospital by 5, round at 6, get to ORs by 0730, observe operations, eat between surgeries, evening handoff at variable time from 4-6pm. Leave hospital, maybe read, eat, sleep. It's kind of crazy hours compared to most 'regular' jobs.]

Nonetheless, I am learning some cool anatomy via pimping. I kind of gradually forgot most of the spaces/recesses and artery/vein connections from way back when I was a M1, so it's a good review. It is interesting how the surgeon almost never pimps the resident. I guess we are there to help the resident learn as well (?) as it could be potentially embarrassing if they were asked something and they didn't know causing them to lose track of a vital part of the operation (because it distracted them somehow). This rotation is definitely giving me a newfound appreciation for the 'larges' (large specimens) that we receive from surgery. The other thing it made me appreciate as well is that surgery really is a team sport. Besides 'us' (pathology) surgeons also highly depend on radiologists, anesthesiologists, other OR staff and other healthcare providers to ensure that surgery goes safely. It definitely gives me a sense of the bigger picture when it comes to patient care, which is the ultimate goal of anyone in the medical field.

On a different note, I was prowling the interwebs and I found two editions of the same book, an autopsy handbook. I suggest it for anyone wanting to know more about anything autopsy. The 3rd and 4th version can be found here and here. I recommend checking out both. Although they are different versions of the same book, they actually have pretty different info/chapters.

I guess suture and knot tying is giving me some weird sort of confidence that by the end of the 3rd year of medical school, I would be able to meet the basic medical needs of a human settlement on an uninhabited land/island away from civilization if I was the only medically-trained person there.

One thing that is helping me get through this rough rotation is my 'light at the end of the tunnel' ... I'm going to Japan in 88 days with my SO, so that is definitely a factor that makes each day a little bit better than the next as it is 'another day' before I get to go back to Japan. Counting down...





Sunday, January 20, 2019

Optics and Tech

To follow up on my previous post, I want to try and imagine the pathology workplace of the future. When the frozen section was invented in the 1890s, doctors hardly could have imagined the workplace of today (2019) 130 years later. In the last century, many advances were made in the field of pathology, aided by the increased availability and means of communication and exchange of ideas (telephone, radio, television, and most recently, computers and the internet became widespread). A century before that, dyes originally invented for the textile industry were applied to biological specimens. About one to two centuries before that, the microscope was invented.

Now, I would like to discuss the possibilities and logistics regarding what I believe to be an eventual and inevitable transition from traditional microscope viewing of physical slides to what I shall loosely call 'digital pathology'.
First of all - I want to note that pathologists have a central role in shaping how we want the 'workplace of the future' to be.  
Secondly, I believe that this is a process which must evolve organically given new developments in technology which are happening on a daily basis in our time. 
Third, there are crucial mistakes to be avoided if digital pathology is to 'get off the ground' so to speak.  
Additionally, I do know that there are opponents (read, older pathologists) who often harbor mistrust of new technology (i.e. computers) because they are set in their ways. The pathology workplace of the future should be so foolproof (read, solid) that a late-career pathology could walk into this fictional futuristic workplace and be impressed and amazed at its capabilities, and excited about the future of pathology and the possibility of working in one of these places.

While radiologists get a bad reputation for being in 'the dark room' perhaps we as pathologists have something to learn from them, as both are highly visual specialties. By reducing the amount of bright light exposure, radiologists have attempted to create a workplace in which a certain type of eyestrain is reduced (but not due to squinting), the details of the surroundings are obscured and their visual attention is focused on what is being assessed. In a similar manner, pathologists desire (or should I say, require) an immersive experience when we are looking at tissue through our microscopes. This, I believe is why pathologists tell me, books cannot compare to looking under the scope. What is seen is much larger when looking under the microscope compared to a picture in a book, moreover there are fewer distractions. A similar phenomenon is when one holds his or her cell phone close to the face, in effect 'blowing-up' the screen.

The fairly recent invention of VR headsets could be a game-changer in this regard. Or take augmented reality implements (such as google glass). I envision something akin to wearable sunglasses, with digital slides projected on the lens, with built in eye movement tracking in order to navigate a slide. Additionally, there will be no keyboards or controls, a pathologist will use simple hand gestures/movements which are read by sensors in the 'room' which serve as 'shortcuts' to navigate back and forth between slides (or if preferable, voice commands). Alternatively, imagine just thinking about magnifying a certain region of a slide and it happening instantaneously -- this requires nascent technology which I will elaborate on further.

Other key considerations which radiologists have heartily adopted, and pathologists should also, have to do with ergonomics and equipment. For example, on my recent visit to the radiology department, I was impressed by their adjustable table heights and comfortable chairs. An simple adjustment many pathologists can make without any fancy equipment is to obtain an adjustable microscope stand (but one might need an adjustable eyepiece as well depending). Comfort improves concentration and makes already heavy work feel lighter somehow. Importantly, they have also invested in state-of-the-art viewing equipment. Even for teleradiologists, to read at home, they must have a monitor (or monitors) which meet a certain specification in terms of quality. This is analogous to microscopes, which can be very costly, but when the inevitable transition to 'digital pathology' occurs the 'viewing station' may become very different.

Another innovation which radiology has gotten down pat, is the use of a universal file type which enables the easy sharing of information between different hospitals/medical centers. For example, one can obtain the images which were acquired in one location, and easily transfer/read the very same image in a different location because of the very fact that the filetype is the same. A simplified example of this is extensions in computer programs. For example .doc means document and can be opened by any program which can read document files. In the same manner, pathologists should decide and insist on standardization of digital slide filetype which would enable universal sharing of such information (although I wonder and hope the companies commercializing slide scanning have already decided upon this).

The final point which I would like to make is with regard to the speed of formulation of reports, and in a very real sense has to do with communication, and this is again is where the imagination part comes in. It has been shown that the human brain thinks much faster than it speaks. Additionally, I think we can all agree that one in general speaks faster than one types (hence dictation), one types faster than one writes with the hand (hence typing and writing), and that one reads, writes, speaks, and thinks faster and with more accuracy the more one uses each faculty. Regarding the conveyance of information and the formulation of reports, I wonder if in the future pathologists will be able to think up/down a report (this may require the invention of a new word).

Returning to my point of elaboration, which I referred to earlier, research is currently being done on the conscious control of objects, whether real or virtual, using brain waves. This is also called many different names, however I will use the term which I find most fitting, a mind-machine interface. It could be imagined that in the future, mind-machine interfaces will become commonplace, and eventually applied to pathology workflows.

The pathology workplace of the future may require the use of a real life, state-of-the-art 'thinking cap' which includes a built-in viewing station and neural net/hat (similar to an EEG monitor) conjoined, which would allow a pathologist of the future to complete reports much faster than before. Old pathologists will tell you, once pathology transitioned from hand-written reports to typing and eventually dictating, how turn-around times (TAT) decreased and subsequently the expectation of clinicians for same-day/the-day-after results became commonplace. If thought to text conversion is accomplished within our lifetime and applied to pathology, I believe pathologists will become ever more efficient at their jobs. Not one, but all of these in combination, and with the incorporation of yet-to-be invented technologies, all are innovations which would revolutionize pathology as we know it today.

If one makes an another analogy to radiology, one could say radiation exposure is the main limitation in conducting scans of the human body; nevertheless, advances in imaging technology (MRI, low-radiation CT) have allowed less radiating (though more costly) scans to be acquired. Radiology differs from pathology, however, in that a patient is a potentially unlimited source of scans. Moreover, the demand for scans and imaging results has on-the-whole been increasing (part of this is due to greed, and the other, negligence on the part of radiologists to serve as gatekeepers of healthcare resources). Because of these practices, modern radiology is now the practice of normology, in which one sees much more normal than 'bad' as a radiologist. The bottleneck in pathology is that it as a practice requires precious human tissue. Because I do not see resections going away anytime soon, I anticipate pathologists in the future having more time for research and academic pursuits, mentorship, safety/infection control, hobbies or perhaps even an improved lifestyle which would be pretty nice.

A very important cause which I believe all pathologists (who care) must fight for, if these changes do occur, is recognition of our speciality as being the foundation of medicine and the bridge between basic scientific research and other specialties of medicine (see the tree of medicine). And in addition, pathologists must prevent of the creation of 'mills' in which pathologists are made to work tirelessly to enrich others, from outside or within medicine itself. Technology has the power to unite people, under a common cause/interests in order to enact change.

P. S. A disturbing scenario involves the monitoring (Orwell's 1984) or de-privatization of thoughts (a.k.a. mind reading). A very dark episode (no. 1) of the anime Kino no Tabi tells the story of a town in which people automatically know each others thoughts. Would brain-computer interface technology develop to the point in which this could be enabled? Food for thought.

Dermpath and AI

Hi everyone,

This weekend, I'm reading Practical Dermatopathology by Ronald P Rapini. It seems a very well organized book. There is an interesting analogy in the book. It says:
Pathologists may be subcategorized into home-run hitters and hedgers. The home-run hitters try to "force" a diagnosis, and give only one most likely diagnosis. They are either very, very correct, and look very smart, or else they strike out and miss the diagnosis completely. This can be dangerous. For example, they might diagnose a lesion as a definite Spitz nevus, which subsequently is found to be a melanoma when it metastasizes. Most Spitz nevi can be diagnosed with relative certainly, but there are always those difficult cases for which all the experts can have their opinions, using the best of criteria, but for which there remains an element of uncertainly. Simple histology has its limits in predicting biologic behavior. Hedger pathologists, by contrast, seldom make a specific diagnosis, and instead often give a long differential diagnostic list, even to the point of listing histologic possibilities that are ridiculous from a clinical standpoint. They rarely strike out, but they are sometimes not very helpful, and are not appreciated by clinicians. Wise pathologists avoid these two extremes.
This reminds me of a concept brought up by a pathology resident, the idea of spotters or 'instant diagnoses' of entities which are instantly recognizable, versus other types of cases that can be more complex. I suppose the home-run approach would work great with spotters, whereas hedging would be most applicable to more ambiguous situations. Another resident told me, 'the best pathologists consider differentials before honing in on a diagnosis'. Essentially, going from good to great requires finding a happy medium. "The art of pathology is to be dogmatic about the diagnosis as often as possible, while not being afraid to hedge and give a differential diagnosis when the diagnosis is uncertain."

Today, I want to discuss the idea of pathology as art, within medicine, involving subjectivity. The reason for this is because of the strange idea that technology, such as high-powered computers or robots, will someday replace pathologists.

People who say pathologists will disappear as a specialty under the threat of AI do not really understand pathology. When this topic inevitably comes up in clinic, and I try to explain why AI would not be a threat to pathologists, it seems the clinicians become disinterested in the conversation. Why this is the case, I am not really sure, since most of the time they were the ones who brought it up as a topic of discussion in the first place, in response to me telling them that I am interested in going into pathology.

Thus, I want to list my personal opinion regarding why I think AI will not threaten the livelihood of pathologists everywhere.

1) Big tumors and sampling - I watched a TEDx talk where the presenter showed machine learning in which the computer was fed images of biopsies, and was able to stratify them in terms of prognosis with some accuracy. There are many judgements which a pathologist must make regarding biopsies and large cases, which a machine is incapable of. A machine is capable of producing output based on the data given to it previously, however, would it be able to determine whether a biopsy is adequate (in other words, representative of the lesion) [absence of data], or when it comes to larger specimens, whether the tumor has been adequately sampled during grossing? For some reason, I find it hard to believe that a machine would be able to determine whether additional sections of a large tumor need to be put in. These are judgements which an experienced pathologist makes easily and instantly when assessing a case.

2) Ontology and context - a machine does not understand the true meaning of what it sees. Yes, a person (i.e. computer scientist) can assign different values to data within the program/algorithm. However, truly understanding disease processes is something I cannot see a machine doing now or in the future. For example, a pathologist notices that a prior biopsy or sample had changes similar to the one he/she is noticing today, and based on the patient's lab tests and chart, concludes that the patient has a particular disease. The pathologist is able come to this conclusion based on a compilation of disparate sources of information, observation, analysis, and medical knowledge.

This brings me to the next two points.

3) Stains and artifacts - A machine (read, computer) does not know what is plausible or implausible. Preparation artifacts occur on a daily basis. Yes, a machine could be taught to recognize these, but there may be misinterpretations because of the variable presentation of such artifacts, given that they may range to subtle to overt. This highlights the often undervalued role of the pathologist as serving in QC (quality control) of the histology lab where slides are prepared. Pathologists are the arbiter of what is allowable in the quality of histology slides that are made for diagnostic purposes, for only pathologists have the privilege of conferring diagnostic meaning to a slide. Moreover, there are many mimics in pathology. Would a machine be sophisticated enough to distinguish these. Lastly, stains which require the use of a polarized microscope/direct immunofluorescence (DIF), I see a machine struggling to interpret given that it is based on light pattern and intensity.

4) Communication - One of the jobs of a pathologist is to serve as a liaison between clinician and the laboratory given the clinical context, in instances calling the clinician to get more information or recommending the appropriate ancillary testing, or simply communicating results in tumor boards, etc. Appropriate communication is something machines still have not mastered, just note our communication frustration with Alexa, Siri, and Google Home and various other voice activated/dependent products on the market currently. Formulation of reports are also important methods of communicating to clinicians in a concise, accurate fashion our assessment of a particular case. I feel doubtful that a computer or machine would be able to fashion a report which serves to be a useful consult to a clinician.

From my experience in pathology thus far, I feel AI will be a helpful adjunct, which may increase the efficiency of existing pathologists. Where I do see AI playing a role, is in removing some of the tediousness of pathology, and introducing more standardization, for example in the interpretation of stains such as HER-2 IHC, where there is interobserver variability. Just like AI was slotted to make radiologists "extinct" years ago, when radiology was brought from the 'dark ages' of silver-stained films to digitalized imaging and reading rooms, pathology is similarly on the cusp of making the transition from physical microscopes and slides to completely digitized workstations. Just see how they do it in Belgium.

One of the revolutions in pathology which I think will happen in my lifetime is the advent of telepathology, in which pathologists are freed to live and work in whichever location that they choose while reading virtual slides for a laboratory based in another location. This may help alleviate trainees' concern in pursuing a specialization which may not be particularly in demand, or concerns about finding a suitable position in a desirable location. Overall, the advances of modern day (tech revolution) hold a lot of promise as a tool for education as well, and I am excited to see how far the next generation of pathologists take this.

Saturday, January 12, 2019

Lung path

Hi guys,

Been going over lung pathology using Foundations series book and Sanjay mukhopadhyay's Youtube channel. I want to correlate with cytology, but not sure about resource to use besides DeMay. What would be really good would be an atlas with cytopath correlates. 

Lung is a deceptively "simple" organ. It looks simple on H&E, but now I know there is way more than meets the eye... Autopsies, I feel, really help in understanding the lung in disease given it is pretty rare to get a full lobectomy specimen on a living patient. In that sense, it is somewhat (but not completely) like the brain. i.e. full brain, you know, person = 100% dead; Whereas, lung-wise person ≈ dead, remember you need two. But yeah... It is nice seeing coronal gross slices of lung, in an Autopsy Atlas, for example. Even better to see multiple slides (but not so nice for the patient). It is kind of unfortunate that there aren't more lung pathologists, but I understand it because of the volume. 

I'm interested in how the discovery of PD-L1 will change the field of lung cancer / pathology. The lab at my home institution is trying to bring PD-L1 IHC (immunohistochemistry) in. Perhaps if there was a method that was faster (molecular anyone?) it might be worth a pretty penny. Essentially, since the technology is so new, I feel like there are many directions to take this... investigation into better IHC markers as surrogate or improved over PD-L1 perhaps, or perhaps even a new technique, or a way to standardize it, would be helpful... though I'm guessing pharma R&D are all over this right now. Just a hunch.

What are some new developments you all have noticed recently?

Side note: Was recommended this book (Diagnostic Pathology: Kidney Diseases, 2nd Edition) by Robert Colvin at MGH. Along with Silva's renal path and Heptinstall's. All seem like great books for learning renal path. It's hard to find these books, but I suggest interlibrary loan if available where you are... another resource is WorldCat, which is a worldwide catalogue for books in libraries around the world.

Friday, January 4, 2019

Books

Hi everyone,

Happy 2019!

Today I wanted to post about books.

For surgical pathology, my top 4 recs

Foundations in Diagnostic Pathology series
AFIP fascicles (Atlas of Tumor Pathology)
WHO Classification
AJCC 8th edition

It may be worth going on WorldCat or requesting via interlibrary loan if one wishes to read the physical copy. However, I don't think it is worth buying immediately as the copies are updated every few years and it is worth waiting until residency to buy and only when you need to (buying WHO when starting hemepath rotation, for example).

I was actually quite surprised to find that the library at my medical school had a few physical copies of the Foundations series in addition to the big DeMay cytology textbooks (also recommend). I think there is a smaller, condensed version (Breviary in Cytopathology).

I do feel it is good to get information from different sources, as pathology changes constantly. Staying up to date is a difficult, but necessary task.

It is very interesting as there are a few entities in pathology in which the name has changed recently to be more PC (politically correct) or less confusing and if you talk to a pathologist who has been around a while, they use the names interchangably or just the 'old' name. From the perspective of a young person entering pathology, I think it is better to use the 'new' name, to minimize confusion, however. It also shows that you are keeping up to date with new trends and developments.

What books do you recommend?

P.S. I hear books by Cambridge (publisher) for pathology are good, but can't get my hands on any copies.

Saturday, December 22, 2018

X-mas post

Hi everyone,

I am officially done with my neurology rotation!

Went to a Christmas party with the rest of the medical students yesterday night to celebrate.

The school is giving us 2 weeks of break. I'll finally have time to sit down and read a book 'cover to cover' as they say. Have a list of personal to do's before getting back into the swing of things.

I've recently been getting into Blancpain ladies watches, maybe I could visit their boutique over the break.

Other thing I wanted to do was donate blood... I actually showed up one time to the Red Cross on a random day after I had an appointment at school, and I couldn't donate because it wasn't a 'blood drive' day. I didn't know you had to coordinate the timing.

Other than that, I need to get my hands on some pathology books before starting my next rotation, which is in pathology at my home institution. I haven't looked at a slide in a while.

So plan for today is school library and red cross

Merry Christmas~

So I ended up donating today, but like years ago when I donated in college, I was hard to get blood from (#tinyveins). They only got about half-a-pack from me, even though I drank extra fluid this week. Person said to try the other (left) arm next time (I figured my dominant hand might have larger veins), and hydrate. From reading forums online, I guess they can probably use it for pooled products (platelets, clotting factors, albumin). Hopefully next time, I'll be able to reach 500 ml. The reddit has some good tips on what to do beforehand. Well it was only my second time donating so, if I donate again, maybe it will go better.

Fun facts: I'm O+.
You can donate whole blood every 56 days.
You aren't allowed to donate if your iron is too low.
There is a Blood Donor phone app from the Red Cross.
Red Cross FAQ   Stories
Reddit for blood donors, potential and existing
Blood Bank guy <-- for those interested in CP

Blood types have been popularized in Asian countries to be a determinant of personality type similar to horoscopes. Just see the comic/show Blood Type ABO!

Sunday, December 2, 2018

Harpsichord and the brain

Hi readers,

I have been loathe to write posts as I have been overseas for ~1 week to Singapore on vacation.

Currently I am on Neurology rotation, and I am actually really enjoying it. The hours and other docs on this rotation are very reasonable and I am finally able to correlate some neuroanatomy with clinical presentation which is really just icing on the cake. Stroke 'call' or rapid evaluation for stroke which can occur pretty much anywhere in the hospital would probably be one of the most important functions of having neurologists in the hospital, from what I am seeing so far. According to the attending, Neurology is one of the last bastions of specialties in which the physical exam trumps any imaging findings. i.e. if it's a stroke clinically, you call it a stroke regardless of the imaging. Given the complexity of the brain and the natural tendency for humans (read, radiologists) to make mistakes when faced with complexity, it will likely be one of the last hold-outs. I am not even concerned that a more powerful magnet / technology for imaging will make any sort of difference in this regard. An interesting pathway a neurologist can possibly go with regards to fellowship is neurointerventional, involving using catheters to treat brain disease. This is very interesting to me, as neurology in itself is not a very procedurally-inclined specialty, so the learning curve must be pretty darn high starting to be trained as an interventionist. Nonetheless, a few of the residents would like to go into this, and I say best of luck to them!

Recently, I have rediscovered the music of Domenico Scarlatti and the sonatas for harpsichord, which he wrote towards the end of his life. Very enjoyable.

This being the weekend, I went to the local art museum.
Speaking of which, I was also at the National Gallery of Singapore on my trip.
It was very interesting to see southeast asian subjects portrayed with traditionally European painting methods. I was listening to this on the plane ride back.

So in chatting with my attending, I did inform her about the difficulty of finding a geographically desirable location to practice or even a job as a neuropathologist, though working as a forensic pathologist is greatly enhanced having done training/fellowship in neuropathology. Just see David Dolinak and his wonderful books. She was unaware and it was nice informing her about the realities of being a pathologist in a niche specialty in this day and age. Perhaps it helps explain why there is such a lack of pathologists and especially neuropathologists, when it is such a huge risk to be taking given market forces and demand.

Speaking with them though, it seems radiology and neurology both agree that neuropathologists are a wonderful (but scarce) resource and trusted colleagues. Very happy to hear recognition by other specialties of pathology.

Enjoy~


Sunday, November 4, 2018

Rad-Path correlates

Hi everyone,

I'm on a 2 week rotation in radiology this month. I've been sneaking in reading about bone tumors, which can be notoriously hard to differentiate histologically, and require correlation with radiology and clinical presentation to avoid misdiagnosis. Same thing with brain tumors. Sign out with the neuroradiologist has also been a wonderful review of neuroanatomy for me.

Here are some relevant sites for your perusal:
Functional Neuroanatomy from University of British Columbia. check out the movies, brain cutting
Neuroradiology cases
URochester Rads cases
U Western Ontario (more neuroanatomy)

Picked up a Neuropathology book from the Foundations in Pathology series from the library.
Also, bone tumors are interesting.

For those considering radiology, I suggest checking out these videos:
Radiology school on Youtube  (bone tumors videos are esp. enticing)

Previously I pondered how one should write pathology reports.

The qualities which I feel an ideal pathology report should have are:
(1) accurate, understandable (2) readable and/or succinct, (3) useful to the clinician (4) comprehensive (synoptic when appropriate).

Observing the radiologists dictate their reports over the past two weeks, I think I've gradually come to the conclusion that, when possible, differential diagnoses should be included in more pathology reports when the findings are equivocal.

Perhaps why this is not more commonly done is because it requires a knowledge of the patient's clinical course in order to formulate. Another reason might be due to the personality of the pathologist -- I think many people go into the field because they enjoy the satisfaction of working up a case to effectively narrow a broad differential formulated by the clinican and/or radiologist and come up with a definitive diagnosis.

Certainly molecular diagnostics and immunohistochemistry can help support a diagnosis, but, especially in the field of hematopathology and cytology, so far as I've noticed, there can be multiple interpretations.

I do feel if pathologists take seriously their role as consultants that relay useful information to the clinician, it is not wrong to call or email a clinician for more clinical history/presentation to inform a differential diagnosis, and to indicate our level of suspicion for each.

Pathologists could take a page from the Radiologist's book in this regard. They are more or less experts at communicating their best educated guess and alternate possibilities to the clinician.

Another interesting reporting style which I recently noticed is: reporting comments in the format of a letter addressed to the clinician. Although I personally think this is a good way to include information to patient support groups. To me I think it should be reserved for cases in which the pathologist wishes to educate a clinician on a rare entity or condition. Personally speaking I believe all treatment/management considerations should be a decision made by the clinician and the patient, and neither the report nor the pathologist should comment.

To pathologists reading: what is your favored reporting style?

Monday, September 3, 2018

Gyn, Path & Patient care

Having weathered the gauntlet that is/was my inpatient pediatrics rotation, I have been kind of off the radar. But, lucky me, I just happened to land having family medicine during the one month that has a holiday that Americans have no justification for or idea about its origin: Labor Day!. The 1 extra day this weekend did leave me less sleep deprived to the point where I feel 'encouraged' to write for you, dear readers. So, I want to relate a story from the clinic.

While I was on the EHR software at my Family Medicine rotation site affiliated with not-to-be-named medical center recently, I came across... a somewhat awkwardly worded pathology report. The phrase found in the pap smear cytology report at the end of a reasonably long paragraph was simply: Trichomonas vaginalis. Not positive for Trichomonas vaginalis, not trichomonad organisms are visualized, just name dropped the bug and out.

At first I wasn't really sure what to make of this, whether it was positive/negative or just a transcription error. So, after looking up the appropriate treatment (metronidazole), I brought it up on presenting to the attending/preceptor with the 3rd year resident, sayin' "hey, this lady was [insert] positive for Trichomonas on the pathology report". Only to get a... "we only treat that if the patient is symptomatic." I mean, having T. vaginalis on the path report was simply pretty just served as a record that the pathologist saw it under the scope, it didn't add to a potential diagnosis. To the clinician, unless the patient is clinically symptomatic it's almost as if that line/information wasn't there. So it's really more of a record 'that we saw it', so to speak.

So this got me thinking about priorities, and layout of a pathology report. In terms of priorities, what is a clinician most likely going to want to know from the report?  When it comes to gynecology specimens, clearly any tissue diagnosis be #1 priority. Then Cytology and HPV results. Additional comments or interesting facts can be saved for a comment at the end of the report. Maybe that the pathologist saw Trichomonas  should have been reported in a 'not clinically useful/relevant' section (i.e. comment) instead of in the main report. This is why being a well-rounded doctor makes the best doctors (and pathologists), in being able to prioritize information in terms of clinical relevance.

I have to say, I kind of hate descriptive diagnoses and I'm sure clinicians do too. It feels like (and probably is) a cop out on the part of the pathologist. It is kind of a cover for, "hey I don't recognize how this fits into the bigger picture" or "I simply don't know what this entity is, so I'll just describe it for now". Which is probably not very satisfying from the standpoint of the clinician, or Ob/Gyn let's say, reading the report. From what I understand, pathologists and gynecologists had to sit down at a table and mutually agree upon terms understandable to both their specialties to agree on a shared language in order to communicate in said reports. Otherwise, I wonder if it would all be descriptive?

This brings me to my final point which I noticed with some regularity, and I'm only speaking to my personal experience right now is... Some gynecologists make themselves look pretty bad in the eyes of pathologists.  I can't tell you how many times over the course of the year where I would be sitting at sign out with the pathologist and a slide with almost no tissue whatsoever graces our presence. Most of the time it would be signed out as an 'insufficient' or 'inadequate' specimen... Though it's really embarassing and really a waste of everyone's time when there is a fleck of tissue on the slide and the gynecologist still submits it like it's a bona-fide specimen. It makes me wonder, do they bill for more when they obtain/send a 'specimen' when there really isn't any? Because it doesn't fool me. Just because you put a piece of gauze in a formalin jar, doesn't mean there was anything on it... and I'm pretty sure they know this as well as we do. It's not hard to see that there's almost nothing with the naked eye. It's additionally extremely aggravating for the person grossing the specimen when it is a tiny... tiny... specimen, and it causes a whole lot of hulabuloo when there really isn't any specimen to be found or it gets "lost".

So, all I get from this is some gynecologists and pathologists make life harder for the other, though they have a very dependent working relationship. i.e. one cannot function without the other. Therefore, I think it is important to maintain good communication with all parties involved and make sure the working relationship is appropriate and congenial. That way one gives/receives feedback and collaboration happens to improve patient care. After all, we need each other.

Sunday, August 19, 2018

more transplant

Today I want to discuss another type of transplant.

The reason I became interested in this is due to having exposure to patients who have undergone combined liver/intestine transplants at not-to-be named children's hospital, where I am currently doing my inpatient pediatrics rotation on the gastroenterology service.

Before, I had really only ever thought about isolated liver transplants, most commonly seen in adult medicine due to liver failure or cancer. The need for a combined transplant is something that I did not really appreciate before seeing kids with short gut syndrome in the hospital. Liver transplant can occur by itself, with intestine, and also possibly other organs such as pancreas or stomach (when this happens it is called a 'multi-visceral' transplant).

The children who require a combined liver and intestine transplantation usually have a history of short gut syndrome. Short gut syndrome is essentially when the small intestine is not functioning well or is shorter due to surgical resection. There are many reasons a child might have short gut syndrome. It can be secondary to a variety of etiologies such as necrotizing enterocolitis associated with prematurity (premature infants are particularly vulnerable, because their lungs are not fully developed, and this can cause poor oxygenation of the bowel which allows existing gut bacteria to infiltrate and cause necrosis of the bowel), any sort of atresia (congenital blockage/obstruction of bowel) requiring surgical removal and anastomosis, or complicated gastroschisis (which is essentially when bowel herniates through a full thickness defect in the abdominal wall; in some cases, when the opening is small it can pinch the herniated bowel which loses blood supply and becomes necrotic, necessitating resection). Other reasons have to do with the functioning of the small intestine. There are some kids who have innervation issues (Hirshprung's disease), food allergies (i.e. milk protein), or recurrent infections that make their gut less functional.

Kids that are missing some or, in severe cases, most of their bowel or have less-functional bowel receive nutrition various ways either orally, intravenously (using total parenteral nutrition or TPN), or via tubes which deposit food directly into the digestive system (gastrostomy or G-tube, jejunostomy or J-tube, gastrostomy-jejunostomy or GJ-tube) which are placed surgically.

Some patients with short gut syndrome develop liver failure associated with receiving nutrition parenterally (a.k.a. via TPN). The reason for this is complex, however the current hypothesis has to do with bile stasis in the liver since the gut is not working to digest as much. For this reason, children with failure to thrive are slowly weaned off TPN and while their tube feeds are increased to avoid this issue. Additionally, the lipid component of the nutrition is carefully controlled as to not overwhelm the liver.

Recently, two of the patients on my service were children who had received combined intestine/liver transplants, and both had complications following transplantation. One of them was transplanted at an early age and subsequently developed hepatocellular carcinoma. He was terminally ill and died in the hospital. The other had acute-on-chronic rejection of the transplanted liver.

A phrase doctors like to say is "it's always about the patient". Although pathologists have minimal to no contact with patients on a day-to-day basis, the information pathologists supply to the clinical team is crucial. Another adage is that a physician who treats himself/herself has a fool for a patient.

Can you think of any other instances in which multiple transplants would be indicated? Share!

Materials for PGY-1

 So I matched in pathology and I'm extremely happy!! I'll be posting resources here that I feel may be useful for an incoming traine...